Genotoxicity Studies

Determine if your substrate will influence genetic material or have hazardous affects through genotoxicity testing. Compounds identified as genotoxic have the potential to be human carcinogens and/or mutagens which can cause cancer and/or defects.  Genotoxicity is a requirement prior to the approval of any new drug.  CMIC conducts these studies using a small amount of a test compound expeditiously in initial screening and conducts hepatocyte micronucleus assay in juvenile rats as a second in vivo micronucleus assay.

Ames Test

The Ames test evaluates the potential of a test compound to induce the reverse mutations in bacteria. The Ames test is in compliance with the principles of GLP in accordance with the Industrial Safety and Health Law GLP and the Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture. Ames test are conducted during screening, IND enabling studies and impurity assessments.

Our Edge in Genotoxicity Studies

Efficient Use of Test Compounds

Conduct genotoxicity testing using a small amount of test compound expeditiously during initial screening.

Specialty Assays

Ability to conduct micronucleus assay in juvenile rats as a second in vivo micronucleus assay.