Efficacy Pharmacology Studies

Specializing in efficacy pharmacology studies, testing of therapeutics in cynomolgus macaque disease models. CMIC also provides pharmacological consultation for your research and development programs.

When it comes to designing a preclinical pharmacological study, a well thought out process-flow, appropriate selection of an animal model and well defined experimental endpoints are critical. With our expertise in preclinical pharmacology, your study will be fully supported every step of the way.

Efficacy Pharmacology Studies Provided:

Allergic Rhinitis
Examine the efficacy on the antigen (ovalbumin, OVA) induced immediate-phase and late phase rhinitis (nasal congestion) response, inflammatory cell infiltration to the nasal cavity and vascular permeability in the nasal mucosa using OVA-sensitized animals.

Asthma
Examine the efficacy on OVA induced airway hypersensitivity response, increase of airway resistance (immediate-phase and late-phase), cell count in bronchoalveolar lavage fluid (BALF) and cytokine, and histopathological changes using OVA sensitized animals. In addition, evaluate airway remodeling of long term antigen-induced chronic asthma animals.

Cardiovascular System
Assess antihypertensive efficacy by telemetry and tail-cuff methods (rats dogs and monkeys), X-ray (rats, dogs, monkeys and pigs), Ultrasonography (echo cardiogram) (mice, rats, dogs, monkeys and pigs), Holter electrocardiography to  guide you to the best evaluation model(s) for your study drug or medical equipment (2K1C, Diabetes mellitus etc.).

Central Nervous System
Stroke: Photochemically-induced thrombosis (PIT), Thromboembolic, Transient and permanent occlusion
Neurology: Parkinson’s disease

COPD
Examine the efficacy on the changes in the respiratory function, pulmonary function, inflammatory cell counts in bronchoalveolar lavage fluid (BALF), pulmonary histopathology, and average alveolar size (mean linear intercepts, MLI) using animal models.

• Cigarette Smoke Exposure Model: Mouse, Rat, Guinea-pig
• Cigarette Smoke Solution-Induced Mode: Mouse, Guinea-pig

Gastroenterology 
Inflammatory bowel disease (IBD), Visceral pain/Irritable bowel syndrome (IBS)

Ophthalmic Evaluation
Various model animals such as corneal epithelial detachment, age-related macular degeneration (dry AMD and wet AMD), glaucoma

Pain
Capsaicin-induced acute pain, Oxaliplatin-induced polyneuropathic pain, Postoperative pain, Peripheral mononeuropathic pain, Osteoarthritis (OA)

Pulmonary Fibrosis
Examine the efficacy on the changes in the respiratory function, pulmonary function, lung hydroxyproline and pulmonary histopathology using bleomycin (i.t. or i.v.) induced animal models.

Skin Care Evaluation
Various model animals with atopic dermatitis, dry skin, sunburn (UV irradiation) and alopecia (hair restoration and hair growth).

Other Therapeutic Areas
Thrombosis​, Chemically-induced pruritis, Specialized dosing

• Study protocol design utilizing a NHP disease model
• Study planning and execution