Oligonucleotide Services
Oligonucleotides at CMIC Chicago, IL Laboratory
Advanced Oligonucleotide Assay Services
At CMIC’s Chicago-based Bioanalysis Laboratory, we specialize in providing top-tier oligonucleotide assay services. Oligonucleotides, the building blocks of DNA and RNA, are crucial in various fields, including molecular biology, biotechnology, and medicine. These molecules drive innovation in research, diagnostics, and therapeutic development, offering promising solutions for treating genetic disorders, cancer, and viral infections.
What are Oligonucleotides?
Oligonucleotides are short sequences of nucleotides that play diverse and significant roles in modulating gene expression, protein function, and RNA processing pathways. Different types of therapeutic oligonucleotides include:
- Antisense Oligonucleotides: These molecules bind to specific mRNA sequences, blocking the production of disease-causing proteins.
- siRNA (Small Interfering RNA): siRNAs can silence genes by degrading mRNA after transcription, preventing translation.
- microRNA Mimics or Inhibitors: These modulate gene expression by either mimicking or inhibiting endogenous microRNAs.
- Aptamers: Short, single-stranded DNA or RNA molecules that can bind to specific targets, including proteins, with high affinity.
- Splice-Switching Oligonucleotides: These can modulate the splicing of pre-mRNA, altering gene expression patterns.
Connect with the CMIC team to learn more about how we can support your Oligonucleotide projects.
Comprehensive Bioanalysis of Oligonucleotides
Bioanalysis of oligonucleotides requires sophisticated analytical platforms to ensure precision and sensitivity. Our laboratory utilizes a variety of techniques tailored to the specific requirements of each oligonucleotide type:
Chromatographic Techniques
- LC-MS/MS
- LC-UV
- Hybridization LC-FD
Molecular Biology and Probe Hybridization Assays
- qPCR
- Hybridization ELISA
- Hybridization ECL
- bDNA
Our Expertise and Distinction
What sets CMIC apart is our extensive experience and industry leadership in oligonucleotide analysis. Over the past 12 years, we have partnered with global leaders in RNA-targeted discoveries, developing and validating hundreds of oligonucleotide studies across a broad spectrum of matrices and tissues, including plasma, blood, serum, urine, CSF, kidney, liver, lung, lymph nodes, bone marrow, feces, testis, ovary, uterus, brain, heart, and spleen.
Our comprehensive services include method development, method qualification, method validation, and both Non-GLP and GLP sample analysis. This ensures the integrity and accuracy of data, which is crucial for advancing oligonucleotide therapies.
Specialized Knowledge and Techniques for Oligonucleotides
Our team’s expertise extends to various chemically modified oligonucleotides, which enhance drug stability, improve pharmacokinetics, and optimize target binding. These modifications are essential for the efficacy of oligonucleotide-based therapies. We are proficient in analyzing a wide range of oligonucleotide types, such as:
- Antisense Oligonucleotides
- siRNA
- miRNA
- Decoy Oligonucleotides
- Aptamers
Looking for more detailed information for your upcoming project? Connect with our team of experts.
