The JSMO is a tumor-agnostic academic society concerned with pharmacologic therapy, and is mainly led by doctors of internal medicine. The theme of this 21st Annual Meeting is “Break the Borders and Beyond: for our patients.” We will break down all the borders of nationality, status, specialty, profession, treatment modality, and others to engage in conversation and discussion and open new paths to the future before us, as part of one world. What then lies ahead is a bright future, both for cancer patients and for us.