Pharmacodynamic (PD) Biomarkers
CMIC Chicago Biomarker Solutions
PD Services
Biomarkers for pharmacodynamic (PD) determinations are crucial indicators that play a pivotal role in understanding disease processes, evaluating treatment responses, and predicting patient outcomes. They encompass a wide range of molecules, including proteins, nucleic acids, metabolites, and cellular structures, that can be measured in biological samples. At CMIC Inc., we recognize the significance of biomarkers in advancing scientific research and drug development, and our dedicated team of experts is committed to providing comprehensive biomarker services tailored to meet the unique needs of your projects.
CMIC supports exploratory research by offering qualified or validated assays covering both non-clinical and clinical studies. We understand that reliable kits may not always be available for every biomarker of interest. In such cases, our experienced team develops robust in-house assays using vendor-supplied antibodies to create assays tailored to your specific needs. These assays can be designed as individual assays or multiplex, and we pride ourselves on overcoming the challenges of even the most stubborn assays. With our extensive experience in measuring over 50 protein biomarkers in various matrices—including serum, plasma, urine, blood cells, and tissue lysates—we are well-equipped to assist you in selecting the best biomarkers for your programs.

Method Development and Transfer:
At CMIC, we offer a range of analysis platforms to suit your biomarker analysis needs, including chromatographic, ligand-binding assays, flow cytometry, qPCR, and enzyme assays. Our expertise spans across multiple matrices, including serum, plasma, urine, blood cells, and tissue samples. Whether your focus is on oncology, immuno-oncology, immunology, neurology, or beyond, our team has the knowledge and experience to support your biomarker research every step of the way. If you have an unusual biomarker, we can develop a method from scratch to quantify it. If you are looking for common panel of biomarkers, such as cytokines, we can leverage our experience with existing kits.
Method Qualification and Validation:
Our services encompass fit-for-purpose method qualification or validation to ensure that your biomarker assays meet the highest standards of accuracy, precision, and reproducibility, according to current industry recommendations. We work closely with you to understand your specific requirements and tailor our approach to deliver customized solutions that align with your research goals.
Sample Analysis:
CMIC offers comprehensive sample analysis services to generate reliable data for your biomarker studies. Whether you require analysis of a small number of samples or high-throughput screening of large sample sets, our team is dedicated to delivering timely, accurate results to support your research objectives.